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Biden isn't the only politician who publicly fought legalization of marijuana. However, in politics (as in life) it's important to to remember to "never say never". Another political axiom is "follow the money", and here is where those two sentences merge:
When John Boehner was Speaker of the House, he was strongly opposed to the legalization of marijuana. After he got fed up with the House Freedom Caucus and quit, he started to get lots of job offers and opportunities to make money.
One of those opportunities came when he was invited to sit on the board of a company called Acreage Holdings, a marijuana investment firm whose sale to a cannabis industry giant hinges on Mr. Boehner’s ability to persuade Congress and the federal government to legalize, or at least legitimize, marijuana.
Boehner and former Massachusetts governor Bill Weld each hold 625,000 shares in the company. Boehner currently earns about $400,000 a year due to his position on the board of tobacco giant Reynolds American, and he also earns more than $1,000,000 a year in retirement benefits from Congress. However, if marijuana legislation gets looser in Congress, and if Acreage Holdings gets sold to a Canadian company named Canopy Growth, Boehner will have a very nice payday. Canopy Growth is a Canadian company that is the biggest cannabis holding in the world. The deal, worth around $3 billion, based on current stock prices for both Acreage and Canopy, would create an $18 billion behemoth. If the sale goes through, Boehner's shares would be worth roughly $20,000,000.
Money talks, and b*****t walks.