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Extermination of ISIS/ISIL is what you are speaking about. This very hard because ISIS hides among other Muslims that are children, women and men who have no desire to fight, but be true to their Islamic belief of peace. I know its hard for many a American to believe this, but it is true. The problem with the war going on with ISIS is that it attaches to all Muslims around the world. While ISIS hides among the innocent Muslim people, our conflicts and attacks endanger the Muslims that are not our enemy. Many Americans become trained by our politicians, such as Trump, and those that are bigoted and racists are blaming all Muslims. This only fuels the ISIS agenda and promotes revenge attacks on all of us that attack Muslims.
So, who ever wants to exterminate ISIS, better be ready to accept all the innocent Muslims that get caught in the attack. America, France, Britain, Russia and Australia are very capable of exterminating ISIS within the Middle East. A nuclear weapon is very capable of doing extermination. The larger problem is few ISIS are killed and more innocent Muslims are killed. The other spectrum is ISIS plagues other countries and regions around the world. ISIS is like a disease that humanity has not found the cure or vaccine. I often hear in medical reviews that new vaccines using nanotech are released into the human body and can destroy cancer cells. As related to our world issue of ISIS, we need a similar cure to the entire world, where an agent locates ISIS and destroys it wherever it is found. Currently, the world is playing whack-a-mole in trying to destroy ISIS. Since ISIS has no compromise agenda other than convert to their lifestyle of Sharia Law or be killed. That can never be negotiable.
So, maybe extermination of ISIS is the right agenda for all the world joined to defeat them. However, the response that we have never annihilated anybody before is just false. Ask the Japanese where two nuclear weapons where used on Japan's larger cities. That incident was annihilation even though there were survivors living with decades of pain and death. ISIS would enjoy if their opponents would use a nuclear weapon. ISIS would use that to their advantage and mobilize more around the world. I still believe that the best attack is their funding sources and destroy their hubs of the organization. The fighters the employ are ignorant, but trainable. Take away the money and the organization and ISIS will fall away as a bad dream.